@KarenWV, you asked about tissues.
We buy the square boxes of tissues, and each one that guests have access to is in a cleanable tissue box cover (which means no fabric-covered tissue box covers). The cover gets cleaned off between guests. One bath has a copper cover, one has a ceramic cover, and the two guest bedrooms have ceramic covers. The family room tissue box also has a ceramic cover.
So no guest ever touches the actual tissue box. Since the tissues come out one at a time, I don’t think leaving a partial box for a new guest is unsanitary.
As others have said, we always start each guest’s stay with a new roll of toilet paper on the roll.