I get a lot of one nighters and also board dogs in my home so sometimes it is a bit much. It was a huge help to me to put a private entrance to the room and add a bathroom. Yes, a big investment but it will have paid for itself in less than 2 years. As a result I don’t have to clean the whole house. It only takes an hour max to turn over the room and bathroom. If you can’t do that maybe remove kitchen access? Or put up some sort of temporary room divider screen so people can’t see/won’t enter all parts of your home.
Raise your price a bit. Maybe you lose out on a booking or two a week. Lower it again when your high season is over.
Have plenty of extra linens so you don’t have to wash every day. Don’t iron everything. I don’t and I don’t think budget travelers expect crisp ironed 600TC sheets. They expect clean, that’s it. Maybe clean areas like entries a little less. Trade a couple of 4 star reviews (because they saw a dust bunny in the hallway) for some rest.
I assume you get a lot of last minute bookings as people are road tripping. As soon as you get a booking block off the next night to give yourself two days to recover.