My neighbour has done this as she goes away for the whole Summer (and our daughter does it in France) They both have children so market the houses to families who are delighted to find toys that their kids can play with and also house that is, shall we say, a little less than immaculate!
My neighbour has a very good support network, which I think is helpful. Her business partner manages it for her and meets guests with keys, she has an ex-housekeeper who does weekly and turnaround cleaning and whose husband will do garden maintenance and anything that needs fixing in the house. Also, although our estate is not gated, we have a very good security guard team who constantly drive around looking for any suspicious activity. I don’t think any of these things are absolutely vital if you’re renting the whole house (my stepdaughter’s house is in a tiny French village and she does the whole lot as she lives nearby) but it certainly does help if you have people you can call on for backup.
Of course, many people do home exchanges which have something in common with letting your whole house (although it’s an important difference that you’re not staying in their house too!) but some of the practical issues like keys will be the same. With a home exchange you’re encouraged to get to know your exchangers beforehand. Guests who are paying might not want to be bothered with this I guess if they could just hire a holiday villa with less fuss … so I think you’d need to reflect this in your pricing.
Can you guess from my long answer that we’re thinking of doing this too?!