@smtucker gave some great advice! Listen to it!
The problem with blocking off the days in advance is you could very possibly lose bookings altogether.
What I mean is this: If you block off a Sunday and Monday, you eliminate everyone wanting to stay on those days. Perhaps a guest wants to travel on Monday-Wednesday. You won’t get that booking because Monday was blocked off. So you limit your guest pool considerably; therefore, you may not book Tuesday or Wednesday.
Maybe someone else can explain this better.
What I do is wait until there is 1-2 days between bookings, THEN bock them off. That does give me some back-to-backs but I can handle that.
As @smtucker said, be sure you have the time. Are you working out of the home long hours? Running kids around town all afternoon and evening? Have elderly parents you are responsible for? I met a woman running a shop who said “breakfast? I throw a granola bar at my kids every morning and run out the door, late - then I’m here at the shop - always at the shop - I just manage to get home long enough to feed the family and then I’m back here”. And what is she doing? Refurbing her basement into an airbnb.
At the least, have extra sheets and towels at the ready so you don’t have to wash everything between guests.
There’s a great thread here called ‘what do you wish you knew’. You’ll get a lot of good stuff from that.