I would def not change my cleaning schedule or block the dates. Since they are only in 1 room, I would add it to your listing somewhere. Make it light and positive. “We do have a cleaning service every Wedneesday to keep our home spic & span, they will clean your room too if you request it” or something. make a bonus of it, rather than an inconvenience.
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… why didn’t I think of this. headdesk
Going to go adjust my verbiage. (Though having a reason to block off dates regularly is nice. But maybe only one night and not two…)