You sound like the opposite of a “fussy” guest to me! This is a very real and not a rare condition, so I appreciate your desire to be practical and very reasonable while merely attempting to minimize your discomfort also appreciate the discussion you opened here, as I’ve learned a lot.
Just a quick related anecdote: while dating my husband years ago, I developed hives and an allergic response every time we cuddled on his couch! No allergies to speak of up to that point in my life. Fortunately it didn’t take me long to discover it was heavily Scotchguard-ed.