I have a room with two twin beds, and one with a queen bed. The twin room is booked more often than the queen room.
I agree the twin room is a bit more work, because you potentially have two sets of bedding to deal with instead of one. What I do with my twin room is list my price for one guest, and then a second guest is an additional $10 per night charge, which brings it up to the same cost per night as the queen room if there are two guests staying.
I find that the people booking the room either need two twin beds don't object to the extra cost, or they are single people booking the room because it is more affordable than the queen room if only one guest is staying.