I disagree with the other comments - you had the artwork tucked away in a closet where it was doing nothing. If you'd had a flood or a fire the artwork could have been ruined. You would have lamented the loss, had fond memories of your uncle and his generosity, and you would have moved on.
What is the worst that could happen if you put the art up for guests to enjoy? A piece gets stolen? I've hosted over 3,000 bookings, probably double that amount if I counted it up correctly, and I've NEVER had anything taken off of a wall, and don't even think I've had anything taken - or at least anything of real sentimental value. I even have laptops and kindles in my places, and they stay where they are put.
So if it's not a real "theft" issue, all that's left is damage. Maybe someone slams a door too hard and one falls off the wall? It's unlikely that the art itself would be damage, just the frames. So you can reframe one, or if they need to match, update all of them with new frames.
I used to have treasures tucked away, like a hand-made crochet tablecloth that was my grandmothers. What am I saving it for? To drape over my coffin? Now I use it in one of my listings all the time - it gets stained, it gets a bit torn and needs a repair, but man do I get comments from guests on it.
I say get that art out of the closet, and on the wall.